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(CCFHIONP) PDT, HIFUSDT, HIFUSPDT anticancer, antiproliferative and antiangiogenic effects in vivo LCA models Figure 4c shows the effects of CCFHIONP on the genes relative expressions of VEGF, TNF alpha, Bcl-2, Bax, Caspase (3, 9), and p53 in all groups under study

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The model is then combined with a comprehensive glutathione metabolism model, facilitating the simulation of quinone redox cycling, and adduct-induced GSH depletion