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The proangiogenic imbalance often occurs at the gene level due to the activation of oncogenes or inactivation of tumour suppressor genes, all the way to cell environmental factors such as hypoxia, hypoglycaemia, cellular nutrient deficiency and metabolic acidosis [34]

Khavinson V.K., et al

Cardiovascular Outcomes: Large-scale studies have investigated their ability to reduce the risk of major adverse cardiovascular events in diabetic populations

Nevertheless, these studies based on insurance databases did not include cystatin C to improve the precision of GFR estimates and lacked DOAC concentration data

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