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10.1146/annurev.pharmtox.44.101802.121851 77 KlimaczewskiC

NAC has been utilised to treat acetaminophen damage because of its antioxidant, anti-inflammatory, and vasodilating properties [63]

For instance, NRF2 inhibitors, such as Brusatol and Brucein D, promote ubiquitination and proteasomal degradation of NRF2, enhancing chemosensitivity in cancers like AML, endometrial cancer, and pancreatic ductal adenocarcinoma

Phosphorylation, ubiquitination, and acetylation are common forms of PTMs that interact and collectively regulate protein function and metabolism within the cell

Another significant group includes carotenoids such as beta-carotene, lutein, and zeaxanthin, which are found in colorful fruits and vegetables like carrots and spinach [203]