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The conversion of homocysteine to methionine requires the availability of choline or folic acid to provide methyl groups, so when folic acid is deficient, cells metabolize more choline, resulting in a deficiency of phosphatidylcholine, a key component of mycelin

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This may lead to a less efficient oxidative phosphorylation process, resulting in the production of more free radicals and reactive oxygen species (ROS) (Reid et al., 2018)

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Dark circles can be more prominent with lack of sleep because the skin has not had time to re-set and the blood vessels in the lower eyelid become more dilated. Now I do it every night