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In a different study, caffeic acid phenethyl ester (CAPE) has shown potential in reducing nonalcoholic fatty liver disease in obese mice by manipulating gut flora

Interestingly, in the remission state, increased levels of Faecalibacterium and Eubacterium rectale were observed (Jiang et al., 2018)

(10) found that in mice fed with a methionine-choline-deficient diet, the expression of -SMA and GPR91 is enhanced, while metformin administration reduced overexpression in the liver, ameliorating steatohepatitis and liver fibrosis in mice

Since the GSH depleted mutants were sensitive to Fe deficiency, the next pertinent point was to identify the Fe transporters that might be regulated by GSH

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