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CINC family constitutes a critical subset of CXC chemokines that orchestrate neutrophil chemotaxis, transmigration, and activation through high-affinity binding to the CXCR2 receptor 31

Severe GI reactions (peptic ulcer, GI bleeding, and GI perforation) occurred in 0.4% to 4.6% of patients without a history of a peptic ulcer or bleed and in 2.1% to 15.4% of patients with a history of a peptic ulcer or bleed

Its mechanism of action centers on activation of the Innate Repair Receptor (IRR), which helps regulate anti-inflammatory and tissue-protective pathways without producing erythropoietic effects

Rosenblatt DS (1995)