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Specifically, SIRT1, SIRT3, and SIRT5 protect the cell from ROS, and SIRT2, SIRT6, and SIRT7 modulate oxidative stress 138,139

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Children and teens Although the prevalence of vitamin D deficiency in children and teens varies by geographic region, studies estimate a prevalence rate of about 15% in children ages 1 through 11 and 14% in children and teens ages 12 through 19 ( Children and teens who have overweight or obesity are much more likely to be deficient in vitamin D than children who are considered to be at a healthy weight ( irritability developmental delays bone fractures slow growth muscle pain Its important to note that vitamin D deficiency may be more apparent in young children than adolescents, as many teens who are deficient are asymptomatic or have vague symptoms