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however, caloric restriction is marred by poor compliance, impacting human translatability

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doi: 10.1089/thy.2014.0525 101 MandelSJMandelL

Elevated levels of total immunoglobulin E (IgE) and pro-inflammatory cytokines such as interleukin (IL)-4, IL-13, IL-22 and IL-31 can increase ROS production and vice versa, further contributing to the pathophysiology of AD (20, 24)