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Description

The ex vivo fluorescence signals of the organs and tumor were collected with a live fluorescence imager

Meclofenoxate hydrochloride (MH) and sodium phenylbutyrate (SP) restore the normal expression levels of PD-associated genes via different mechanisms From BR7M4, we extracted DEGs for the discovery of PD candidate therapeutics (Supplementary Table 9), from which two drugs, SP (connectivity score 0.963 and ranked in top 0.05% of 6100 drugs) and MH (connectivity score of 0.814 and ranked in top 0.2% of 6100 drugs), were considered for further validation since they were not only top-ranking candidates but were also able to pass through the blood brain barrier