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In addition to mock-transfected cells, each plate contained control siRNAs targeting either paxillin or cofilin-1 + destrin, as well as a cell-death inducing siRNA mixture (AllStars Hs Cell Death siRNA, Qiagen) at a final concentration of 25 nM (see Extended Data Fig

doi: 10.1016/j.resmic.2013.03.009 135 JametA.JoussetA

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FIGURE 1 Platinum accumulation in dorsal root ganglia The accumulation level of Pt drugs in DRG is 1020 times higher than that in other nerve cells, which could be attributed to the high expression of Pt-related transporters (e.g., Ctr1/2, OCTs) in DRG (Trecarichi and Flatters, 2019)

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