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Lipid metabolic imbalance leads to lipid accumulation in the liver, resulting from steatosis due to non-alcoholic fatty liver disease (NAFLD)

DNA and RNA are also damaged via purine and pyrimidine oxidation, protein-DNA crosslinks, single- and double-strand breaks, and RNA folding perturbations, all of which compromise gene function and signal transduction (99)

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All evidence examined to date appears to suggest that viruses are ancient and may even predate LUCA [9092]