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Adv Sci (2023) 10:2304289

Just like cyanocobalamin, it has to be reduced from state +3 to +1 before it can become either methyl B12 or adenosyl B12

doi: 10.1016/j.prp.2023.154497 205

It accepts the now-known solution concentration plus subject-specific variables (e.g., body weight in animal research, or unit-based dosing) and returns the volume to draw per dose

Routine aspiration is no longer recommended by the WHO or CDC for the deltoid, ventrogluteal or vastus lateralis sites, as those sites carry negligible vessel risk