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Interestingly, the expression of IGF-I and IGF-IR is profoundly reduced in the growth plates of the Cart CaSR / mice (44), suggesting that Ca 2+ /CaSR promotes chondrocyte differentiation, at least in part, by enhancing IGF-I signaling (Figure 1)

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Notably, it is FDA-approved for reducing visceral fat, providing researchers with a wealth of clinical safety and efficacy data to draw from

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iv) oxidative stress maybe involved in arrhythmogenic electrochemical processes