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Beyond its initial recognition as a neuroprotective agent, Humanin has demonstrated cytoprotective effects in various cell types, including cardiomyocytes, neurons, and endothelial cells (Chai et al., 2019)

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(A) Schematic representation of coronal sectioning and (C) sagittal sectioning indicating the area of interest, the corpus callosum

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It is commonly studied in experimental models involving tissue repair, inflammatory response modulation, and recovery-related biological mechanisms , making it a foundational compound in modern regeneration research

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the dimer interface which encompasses the inter-domain linker amino acids (K122, D123, Y124, I125, R126, and N127) is referred to as the hinge region (Gherardi et al., 2006

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