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Still, you must note that specific side effects can vary based on the individual, the type of antioxidants used, and other factors

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These compounds induce excessive ROS production by depleting antioxidants, activating enzymatic ROS-generating systems (e.g., NADPH oxidase), and triggering mitochondrial dysfunction, ultimately impairing spermatogenesis and sperm quality ( Figure 1g ) ( Despite their diverse origins, both endogenous and exogenous factors converge on a common pathogenic pathway: by inducing mitochondrial dysfunction, activating enzymatic ROS-producing systems, or impairing antioxidant defenses, they lead to excessive ROS accumulation

The TH production, per se , is a high source of ROS in the thyrocyte