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Reduced levels of frataxin in FRDA patients are associated with defects of iron-sulfur cluster (ISC) biosynthesis (Bradley et al., 2000), mitochondrial iron accumulation in heart and dentate nucleus (Foury and Cazzalini, 1997

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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations BPD: bronchopulmonary dysplasia H 2 O 2 : hydrogen peroxide HO : hydroxyl radical NAC: n -acetylcysteine NOX: NAD(P)H oxidase ROS: reactive oxygen species SOD: superoxide dismutase O 2 : superoxide References Sola A, Rogido MR, Deulofeut R 2007 Oxygen as a neonatal health hazard: call for detente in clinical practice

Disrupted function of lactate transporter MCT1, but not MCT4, in Schwann cells affects the maintenance of motor end-plate innervation