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Gastroenterology 98 :14521459

Mukherjee, A

These models contribute to the 3R concept [refinement, reduction and replacement] of animal experimentation which leads to reduction of animal utilization for research purposes [14]

These results suggest that alcohol can cause loss of intestinal barrier function by extracting and dissolving intestinal mucosal lipids with a resulting decrease in the hydrophobicity of the mucosal surface, which is a critical component of intestinal barrier function [67]