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mDCs, including cDC1, cDC2, and cDC2b, exhibited the largest percent increase in circulating 4 7 + cells in VDZ-treated patients (Fig

Across the cagrilintide clinical program, the dominant tolerability issues have been gastrointestinal: nausea, reduced appetite, constipation, and, less commonly, vomiting a profile shared with pramlintide and with GLP-1 agonists, and mechanistically expected from a compound that slows the stomach and engages the area postrema

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Monodeiodination activity in relation to cell growth