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Discovery of a first-in-class CD38 inhibitor for the treatment of mitochondrial myopathy

Importantly, PGC-1 over-expression obviously reduced HFD-induced liver tissue damage, collagen and iron deposition, liver functional impairments, MDA formation and restored liver GSH levels in mice, relative to that in the mice fed with HFD and injected with the control AAV8-NC (Fig

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Multiple strategies based on MEK, mTOR and BCL-2 signal transduction inhibition in acute lymphoblastic leukemia (ALL)

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