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Valsartan was without grossly observable adverse effects at single oral doses up to 2000 mg/kg in rats and up to 1000 mg/kg in marmosets, except for the salivation and diarrhea in the rat and vomiting in the marmoset at the highest dose (60 and 37 times, respectively, the MRHD on a mg/m2 basis) (Calculations assume an oral dose of 320 mg/day and a 60 kg patient)

NADPH is nicotinamide adenine dinucleotide phosphate, in the reduced form is a coenzyme that is an electron donor, including drug metabolism mediated by cytochrome P450

It can rarely cause an anaphylactoid reaction , with histamine release due to the direct action of the medication

10.1590/1516-4446-2019-0741 Braz