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Hypoxia signal transduction is schematized in Fig

5 Implications and recommendations for future research As delineated in the text, NNMT is a crucial factor in MetS and has become a promising target for preventing or treating MetS-related diseases

It relies on a caloric deficit created through sensible nutrition, regular physical activity to preserve muscle and burn energy, andmost importantlya healthy, functioning metabolism

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Although the molecular mechanism of BPH have been extensively studied, including a disequilibrium of sex hormone [4], stromal-epithelial interactions [5], cytokins [6], autoimmune [7] and oxidative stress (OS) [8], the exact pathogenesis remains unclear