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Patients who improved after their initial treatment or first retreatment would not have entered these studies, creating a selection bias toward individuals with more refractory illness

Funding Open Access funding enabled and organized by CAUL and its Member Institutions Murdoch Childrens Research Institute,James Cook University,National University of Singapore Ethics declarations Conflicts of interest The authors declare no competing interests

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It also protects against tissue damage by scavenging free radicals and guards against apoptosis