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This impairment cripples the adaptive stress response, effectively lowering the threshold for oxidative damage and rendering airway structural cells markedly more vulnerable to ferroptosis upon encounter with other environmental triggers

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Research indicates that oxidative stress responses can promote the malignant progression of bladder cancer by inducing inflammation, inhibiting antioxidant defense systems, and activating oncogenes, though these effects may be modulated by individual genetic factors (Reuter et al., 2010