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The animal science is real, but calling it 'proven' is a stretch when 99.7% of the research is in rats

and nutrition and clinical medicine can translate these findings into implementable dietary recommendations or complementary therapeutic programs, which can then be verified in clinical trials

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Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum

Other studies have also shown that chronic administration of rotenone over a long period can increase nitric oxide and lipid peroxidation products in the brain cortex and striatum in rats, which then clearly mimic parkinsonian behavioral symptoms such as akinesia and rigidity