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In addition to characterizing a new family of HGF/Met antagonists, this Example demonstrates a qualitative relationship between the ability of a compound to bind HGF and block HGF dimerization and its observed in vitro biological activity

In a 2018 study published in Current Pharmaceutical Design , researchers compared the effectiveness of BPC-157 to that of various standard peptidergic angiogenic growth factors (EGF, FGF, and VEGF) and numerous carriers for treating gastrointestinal ulcer healing and tendon, ligament, muscle, and bone healing

Case reports and small open-label use in clinics pop up online, but without standardized outcome measures, no control groups, and no objective biomarkers

Increased deposition of extracellular matrix and placement of repair cells accelerate recovery

BPC-157 is a synthetic peptide created to mimic a type of peptide found in human gastric juice