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Hypoglycemia as a paraneoplastic syndrome associated with hepatocellular carcinoma is attributed to the secretion of insulin-like growth factor II

IRE1 accelerates the degradation of mRNAs encoding mostly ER-targeted proteins, resulting in a decrease of protein entering the ER membrane during ER stress [109, 110]

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In the apo-OsDHAR structure, the OG atom of Ser23 is 3.4 away from the SG atom of Cys20, which is an acceptable hydrogen bonding distance considering the rotational movement of the side chains of Ser23 and Cys20