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306 Studies have also confirmed that the aminosalicylic acid preparation mesalazine inhibits the levels of proinflammatory cytokines such as TNF- and IL-13 through the IL-6/STAT3 signaling pathway, restoring normal levels of ZO-1 and IL-10 in the colon and improving UC progression in rats

1b,c), indicating that it may engage cellular receptors and function as an immune evasion molecule

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The treatment of anti--synuclein aggregation primarily works to boost the cellular clearance mechanisms and regulate Lewy bodies [49]

However, it does not alter global methylation levels as measured by LINE-1 (Link et al., 2013)