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Mechanistically, Tagitinin C induces oxidative stress and endoplasmic reticulum (ER) stress, leading to Nrf2 nuclear translocation and subsequent expression of its downstream target, HO-1

doi: 10.1089/ars.2009.287 320 SankarPGopal TelangAKalaivananRKarunakaranVManikamKSarkarSN

Similar to other neurologic disorders that are considered neurodegenerative, such as amyotrophic lateral sclerosis (ALS), multiple sclerosis, Alzheimers disease (AD), Huntingtons disease, and Parkinsons disease, major psychiatric disorders, such as schizophrenia, depression, and bipolar disorder, also are neurodegenerative if left untreated or if multiple relapses recur because of treatment discontinuation ( Table )

A fourth protein, DAPP1, satisfied the first criterion, but because we could find no evidence supporting its redox activity, it was not considered further