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doi: 10.1016/j.abb.2013.11.009

Infrequent gene variations have demonstrated a reduction in enzyme activity, resulting in atypical plasticity of glutamatergic synapses and dysregulation of dopamine in the frontal brain

More importantly, brain tissue-resident macrophages, i.e., microglia, possess an alternative ligand for CSF1R (i.e., IL-34), which has been reported to be important to the localized maintenance of tissue-resident macrophages (Xiang et al., 2023)