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Therefore, targeting the HIF signaling pathway and its regulated downstream gene expression has become a potential strategy for treating hypoxia-related diseases

The vast majority of the time, it will show a normal appearing pituitary or a pituitary gland that may be small

Moreover, The depletion of Phosphoseryl-tRNA kinase (PSTK) results in the inactivation of GPX4 and the disruption of GSH metabolism ( in vitro and in vivo ( c /GSH/GPX4 axis in combination with chemotherapeutic agents (e.g., sorafenib) provides new ideas for treatment of drug-resistant HCC

Subsequently, they discovered that inhibition of the PI3K/Akt/mTOR signaling pathway reversed LPS-induced suppression of autophagy, thereby mitigating damage to the intestinal barrier

Cancer Cell 39(3):346-360.e7, 2021