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Obese human and animal models are generally accompanied with abnormal circulating IGF-1 levels [130], as well as IGF-1/IGFBP-3 ratio

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Effect of weekly subcutaneous semaglutide vs daily liraglutide on body weight in adults with overweight or obesity without diabetes: the STEP 8 randomized clinical trial

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People with higher starting weights tend to see faster initial results, while those closer to their goal weight may experience slower but steady progress