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If a severe deficiency is found, a loading dose phase may be recommended, consisting of weekly injections for the first month

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Stanley JA, Raz N (2018) Functional magnetic resonance spectroscopy: the New MRS for cognitive neuroscience and psychiatry research

Obinutuzumab, a fully humanized type II anti-CD20 monoclonal antibody that can induce extensive B-lymphocyte depletion, has been evaluated in clinical trials for SLE, particularly focusing on LN (122)

However, this reaction occurs only when both the H-site and G-site are simultaneously bound to GSH and a slight conformational change may allow ideal coordination geometry of the water molecule in the active site