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Their depletion and functional impairment, driven by a hostile degenerative microenvironment and dysregulated signaling pathways, are critical factors in disease progression

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Notably, a slowing or even reversal of disability stemming from potent medical immunosuppression or bone marrow transplantation should not be necessarily taken as evidence of a primary immune pathogenesis, because reducing a toxic inflammatory overlay could independently slow a picture of underlying progressive degeneration

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5.4 Frequency distributions Figure 7 presents the results in terms of frequency distributions