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Kreutz A, Chang X, Hogberg HT, Wetmore BA (2024) Advancing understanding of human variability through toxicokinetic modeling, in vitro - in vivo extrapolation, and new approach methodologies

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High levels of mtROS may hinder effective antigen presentation at stages subsequent to antigen uptake by directly causing oxidative damage to key proteins involved in pathways such as antigen processing, transport, or loading onto MHC molecules [161]