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This suggests more robust or sustained expression and coordination among multiple CYP enzymes relevant to verapamil metabolism, including the metabolizing enzymes CYP2C8 , CYP3A4 and CYP3A5 , all of which are responsible for verapamil N -demethylation and were highly expressed in h-HepOrgs in DM (Extended Data Fig

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2019) and was therefore used as a positive control