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Both cell types rapidly produced Ccl2 to recruit monocytes and replenish the Kupffer cell niche

pmid:19782547

doi: 10.1203/01.PDR.0000180555.27710.46 37

thus, this state, coupled with the harmful metabolic effects of obesity per se, exacerbates the metabolic and molecular alterations observed during obesity

In animal studies, researchers noted that administration of high doses of ALA via injection to rats decreased the activity of two biotin-dependent enzymes by about 30% to 35%