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Next, we performed correlation analysis adjusting for age and sex to identify any associations between neuroinflammatory and BBB dysfunction markers with BBB permeability assessed using DCE-MRI

Orphanides for critical reading of the manuscript during preparation

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one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy