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381 Surprisingly, statins can decrease the levels of mevalonate-5-phosphate and prevent mutated p53 from binding to HSPs, thus promoting the degradation of structural p53 mutants by MDM2 or CHIP E3

Mirza R, Shah KU, Rehman AU

On the other hand, this toxicity response to AFB 1 is proven by a significant increase in LDH and cardiac troponins leakage from BCMs, as sensitive markers for acute cardiac damage (133)

How these variations impact systemic BA pools and the immune landscape of tumors, particularly those within the hepatobiliary-pancreatic system, and potentially extending to extra-intestinal sites where preliminary associations with BA exposure have been noted (190), needs to be clarified

Table 4 [i] Model 1: no covariates were adjusted