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, in bacteria diminishing returns of epistasis among beneficial mutations decelerates adaptation [148] and lead to an equilibrium of maximal efficiency

Wang and colleagues have demonstrated that the concurrent administration of a GPX4 inhibitor, cyst(e)inase, and PD-L1 inhibition enhances T cell-mediated antitumor immune responses and synergistically promotes ferroptotic death of cancer cells (Wang W

Hammond D, Sasaki K, Takahashi K, Shpall EJ, Popat U, Oran B, Al-Atrash G, Patel KK, Westin JR, Neelapu SS, Valero YA, Chien KS, Daver N, Montalban-Bravo G, Maiti A, Yilmaz M, Jabbour E, Pemmaraju N, Swaminathan M, Ishizawa J, Jain N, Ferrajoli A, Ravandi F, Kornblau SM , Borthakur G, Garcia-Manero G, Kantarjian HM, Reville PK, Abbas HA

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Billesbolle CB, et al