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Both these methylation reactions are vital for growth and cell reproduction.[9][10] Methionine, a sulfur-containing, essential amino acid, is a precursor of S-adenosylmethionine, a cofactor for one-carbon metabolism and the final methyl donor for the methylation of DNA, RNA, proteins, and phospholipids.[11] The methionine synthase plays a paramount role in the synthesis of nitrogenous bases (purines and pyrimidines) involved in the formation of DNA

The Governments 2016 National Diet and Nutrition Survey found vitamin B12 blood levels indicating deficiency in three per cent of girls 11 to 18 years, six per cent of adults 19 to 64 years, five per cent of men over 65 and eight per cent of women over 65

Less common issues include itching or a rash that may signal a mild allergic reaction, or brief dizziness

The side affects appear to be related to the amount of elemental iron and, therefore, preparations that contain less elemental iron tend to be better tolerated