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One aspect of the invention pertains to the administration of one or more NNMT inhibitors by, for example, contacting one or more cells of an animal to: muscular disorders including, but not limited to, sarcopenia, muscle atrophy, Duchenne muscular dystrophy, Becker muscular dystrophy, Limb-girdle muscular dystrophies, Pompe disease, cardiac myopathies, pulmonary disorders

They eat less because their brain receives stronger satiety signals, and food moves through their digestive system more slowly, extending the feeling of fullness after meals

The treatment is very safe, and excess B12 is simply excreted by the body

Their health objectives also play an important role