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Late onset acute GVHD can also occur particularly if DLIs are used to improve chimerism

40 Future directions There is a significant paucity of drugs to prevent ACV associated nephrotoxicity, but NAC showed a promising protective effect against ACV-induced nephrotoxicity in this study

One feedback loop affecting Clk mRNA cycling is mediated by VRILLE (VRI) and PAR DOMAIN PROTEIN 1 expression 10,11 , and another is mediated by CLOCKWORK ORANGE (CWO), which is activated by CLK-CYC 12,13,14,15