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Consequently, Keap1 fails to align with the E2 ubiquitin-conjugating enzyme and thus Nrf2 are no longer targeted for ubiquitination and degradation

A role for glutathione transferase Omega 1 (GSTO1-1) in the glutathionylation cycle

Diagnosis (vitamin B12 deficiency or pernicious anaemia) was treated as a binary response in analysis, as everybody in the pernicious anaemia group was also classed as having vitamin B12 deficiency, as pernicious anaemia is the most common cause of vitamin B12 deficiency

Mitotic cell lysates were immunoblotted to assess if deletion of CEP192 (exon 11) also had a measurable impact on whole cellular, and not only spindle-bound, levels of total and autophosphorylated Aurora-A

This makes S-Acetyl Glutathione a superior choice for supporting liver detoxification