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Mechanism of Long-Term Bruising of the Liquid-Form PCL Bruising is primarily caused by damage to the vessels within the subcutaneous tissue layer, resulting in the extravasation of blood into the surrounding interstitial space

Australian and New Zealand Journal of Obstetrics and Gynaecology , 41 (4), 453-456

Biochem Biophys Res Commun 250:271277 Farris WM, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

While some patients observe noticeable changes within the first 3 weeks, it may take up to several weeks and months, depending on an individuals health and metabolism

[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Everett S.A., Wardman P