how does glutathione s-transferase cause drug resistance in cancer cells

how does glutathione s-transferase cause drug resistance in cancer cells transferases: substrates, inihibitors and pro-drugs and neurodegenerative diseases Frontiers | Multidrug Resistance in

Name: how does glutathione s-transferase cause drug resistance in cancer cells transferases: substrates, inihibitors and pro-drugs and neurodegenerative diseases Frontiers | Multidrug Resistance in
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Frontiers Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches Frontiers Glutamine's double edged sword: fueling tumor growth and offering therapeutic hope The multifaceted role of glutathione S transferases in cancer ScienceDirect Glutathione S transferase Theta 2 causes drug resistance by inhibiting arsenic trioxide induced ferroptosis in pancreatic ductal adenocarcinoma ScienceDirect The Multifaceted Role of Glutathione S Transferases in Health and Disease

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Soluble GSTs consist of two subunits (25 kDa), which are divided into two domains: the N-terminal / forming the G region and the -helical forming most of the H region, which is responsible for the binding of the electrophilic substrate