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Dirr H, Reinemer P, Huber R: X-ray crystal structures of cytosolic glutathione S-transferases

In short, ascorbate functions as a Trojan horse through its conversion to DHA, and insidiously enters cancer cells via GLUT1 to promote the generation of intracellular ROS, which ultimately kills the cancer cell

doi: 10.1016/j.mitoco.2024.07.002 [DOI] [Google Scholar] 112.Greiner JV, Glonek T

Singh et al, 2021), Genes common among published target sets include those related to redox biology (i.e., GCLC , SLC7A11 , TXN ) and the pentose-phosphate pathway (PPP, i.e., PGD , TALDO1 ), in addition to many NADP-dependent metabolic enzymes (i.e., AKR1C1 , AKR1B10 , and CYP4F11 )

Neutralizing antibodies against CD36 almost completely inhibit metastasis in mouse models of immunodeficient or immunocompetent orthotopic human oral cancer [101]