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The components of the Trx system comprise NADPH and thioredoxin reductase (Trx-R), and Trx is regenerated by Trx-R at the expense of reducing NADPH (Holmgren, 1985)

Multiple cell death pathways are involved in the pathogenesis of acute and chronic kidney injury

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the same thing that happens naturally when skin is exposed to the sun or in tanning booths under UV radiation