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While a substantial fraction of CD38+ CD8+ T cells were already detected before the start of the therapy (day 0), the proportion of CD38+ CD8+ T cells increased substantially from 50% to 90% at day 3 after anti-PD1 treatment (Pembrolizumab) in NKTL patient 2 ( Figure 2C )

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Inhibiting NNMT may reduce fat storage and enhance fat metabolism, which would facilitate weight loss andmore importantlyallow for long-term fat loss