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Cell 174 , 497 (2018)

It was proven that the expression of ACSL4 would be suppressed in the early stage of IS, and this inhibition was induced by HIF-1

These alterations reduce ATP production, increase oxidative damage, and render neurons more vulnerable to metabolic stress

It follows that iron metabolism and mean cell hemoglobin concentration, as well as genetic or other factors regulating them, such as blood donation frequency or repletion 74 , could contribute to inter-donor heterogeneity in hemolytic propensity and RBC susceptibility to hemolysis in general, making our findings relevant beyond transfusion medicine