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Several complex I inhibitors have been evaluated clinically and discontinued due to neurotoxicity and adverse side effects (IACS-010759, Tamoxifen, Piericidin A, Phenformin) (76, 77)

Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study

If you have elevated B12 and symptoms like fatigue, weight loss, or abdominal pain, the symptoms are likely from the underlying cause of the elevation , not from the B12 itself

The rate varies, but the trend becomes unmistakable

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